Kubudirira kwesainzi kwepamusoro-soro muunyanzvi hwepamusoro-soro hwekuita deamination tekinoroji, yakagadziridzwa nekambani itsva yezvigadzirwa iri muHeilongjiang, China, yakatsikiswa zviri pamutemo mupepanhau repamusoro-soro redzidzo reNature mukutanga kwaMbudzi 2025. Ichirumbidzwa sebudiriro yepasi rose mukugadzirwa kwezvinodhaka neR&D, hutsva uhu hwaita kuti vanhu vakawanda vatarise nekuda kwekugona kwahwo kuumbazve mamolecular akawanda.
Mhedzisiro yekubudirira iri mukugadzirwa kweiyo yakananga deamination strategy inoyananiswa neN-nitroamine formation. Iyi nzira yekupayona inopa nzira itsva yekunyatsogadziriswa kweheterocyclic compounds uye aniline derivatives-zvinokosha zvekuvaka mukugadzirwa kwezvinodhaka uye kugadzirwa kwakanaka kwemakemikari. Kusiyana nemaitiro echinyakare edeamination ayo anowanzo vimba nekusagadzikana kwepakati kana hutsinye mamiriro ekuita, iyo N-nitroamine-mediated tekinoroji inopa shanduko yeparadigm mukubudirira uye kuita zvakasiyana.
Mabhenefiti matatu ekumira anotsanangura nzira iyi: yepasirese, hukuru hwepamusoro, uye nyore kushanda. Inoratidza kushanda kwakafara pane dzakasiyana siyana dzakanangwa mamorekuru, ichibvisa magumo emaitiro akajairwa ayo anorambidzwa ne substrate chimiro kana amino boka chinzvimbo. Kuita kunoenderera pasi pemamiriro akapfava, kudzivirira kudiwa kwechepfu inokonzeresa kana yakanyanya tembiricha/kudzvanywa zvidzoreso, izvo zvinoderedza zvakanyanya njodzi dzekuchengetedza uye kukanganisa kwezvakatipoteredza. Kunyanya kukosha, tekinoroji yakabudirira kupedzisa kilogiramu-chikero chekugadzira dhizaini, ichiratidza kugona kwayo kune yakakura maindasitiri application uye nekuisa hwaro hwakasimba hwekutengesa.
Iko kukosha kwekushandisa kweiyi innovation inoenda kure kupfuura mishonga yemishonga. Zvinotarisirwa kuwana kugamuchirwa kwakapararira muinjiniya yemakemikari, zvigadzirwa zvepamberi, uye synthesis yemishonga yezvipembenene. Mukuvandudza zvinodhaka, zvinogadzirisa kugadzirwa kweakakosha epakati, kukurumidza kuita R&D maitiro ediki-morekuru zvinodhaka senge anticancer agents nemishonga yetsinga. Muchikamu chemakemikari uye zvemidziyo, inogonesa yakasvibira uye inodhura-inoshanda synthesis yeakakosha makemikari uye zvinoshanda. Pakugadzira mishonga yekuuraya zvipembenene, inopa nzira yakadzikama yekugadzira yepakati-inoita yepakati uku uchitevedzera mirairo yezvakatipoteredza.
Kubudirira uku hakungogadzirise matambudziko agara kwenguva refu mukugadziriswa kwemamorekuru asi zvakare inosimbisa chinzvimbo cheChina mukugadzira-kumucheto kemikari innovation. Sezvo maindasitiri ari kufambira mberi, tekinoroji yagadzirira kufambisa kubudirira uye kudzikiswa kwemitengo muzvikamu zvakawanda, zvichiratidza danho rakakosha kumberi mukushanduka kwepasirese kuenda kune yakasvibira uye inosimudzira maitiro ekugadzira.
Nguva yekutumira: Nov-14-2025