Molecular Editing Tekinoroji Inovandudza Mazana Ekare Maitiro, Inonhuhwirira Amine Yakananga Deamination Tekinoroji Inokonzeresa Shanduko yeIndasitiri Chain.

Core Breakthrough

Musi wa28 Gumiguru, iyo yakananga deamination functionalization tekinoroji yeanonhuhwirira amines yakagadziriswa nechikwata chaZhang Xiaheng kubva kuHangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (HIAS, UCAS) yakaburitswa muNature. Iyi tekinoroji inogadzirisa kuchengetedzeka uye mutengo matambudziko akatambudza indasitiri yemakemikari kwemakore 140.

Zvinokosha Zveunyanzvi

1.Kusiya tsika yediazonium salt process (inoda kuputika uye kusvibiswa kwepamusoro), inobudirira CN bond kutendeuka kuburikidza neN-nitroamine intermediates.
2.Inoda pasina simbi inogadzirisa, kuderedza mari yekugadzira ne 40% -50%, uye yakapedza kilogram-scale verification.
3.Inoshandiswa kune inenge yose yemishonga heteroaromatic amines uye aniline derivatives, pasina kudziviswa nechinzvimbo cheboka reamino.

Industrial Impact

1.Indasitiri yemishonga: Seyo skeleton inokosha ye70% yemishonga miduku-morekuru, kusanganiswa kwepakati pemishonga inorwisa kenza uye antidepressants inova yakachengeteka uye inowedzera mari. Mabhizinesi akaita seBaicheng Pharmaceutical anotarisirwa kuona kudzikiswa kwemutengo we40% -50%.
2.Dyestuff indasitiri: Kutungamira mabhizinesi akadai seZhejiang Longsheng, ane 25% yemusika mugove muanonhuwirira amines, kugadzirisa njodzi yekuputika iyo yakagara ichirambidza kuwedzera kwesimba.
3.Indasitiri yePesticide: Mabhizinesi anosanganisira Yangnong Chemical achaona kudzikiswa kwakanyanya mumutengo wepakati pemishonga yezvipembenene.
4.Zvishandiso zvemagetsi: Inosimudzira yakasvibirira synthesis yezvinhu zvakakosha zvinoshanda.

Capital Market Reaction

Musi waMbudzi 3, chikamu chemakemikari chakasimba chinopesana nemaitiro emusika, nechikamu chinonhuhwirira cheamine chinotungamira zvakawanikwa uye zvine hukama pfungwa masheya zvinoratidza kusimba kwakazara.