Glutaraldehyde Technological Frontier: Kubudirira muAnti-Calcification Technology

Mumunda wekudyara kwemoyo, glutaraldehyde yakagara ichishandiswa kurapa mhuka dzemhuka (senge bovine pericardium) yekugadzira bioprosthetic mavharuvhu. Nekudaro, zvakasara zvemahara aldehyde mapoka kubva kune echinyakare maitiro anogona kutungamira kune post-implantation calcification, kukanganisa kusimba kwenguva refu kwezvigadzirwa.

Kugadzirisa dambudziko iri, ongororo yazvino yakaburitswa muna Kubvumbi 2025 yakaunza riini anti-calcification kurapwa mhinduro (zita rechigadzirwa: Periborn), kuwana kufambira mberi kunoshamisa.

1.Core Technological Upgrades:

Iyi mhinduro inosuma akati wandei akakosha ekuvandudza kune yechinyakare glutaraldehyde cross-linking process:

Organic Solvent Cross-Linking:
Glutaraldehyde cross-linking inoitwa muorganic solvent inoumbwa ne75% ethanol + 5% octanol. Iyi nzira inobatsira zvakanyanya kubvisa tishu phospholipids panguva yekubatanidza-phospholipids iri iyo yekutanga nucleation nzvimbo dzecalcification.

Space-Filling Agent:

Mushure mekuyambuka-kubatanidza, polyethylene glycol (PEG) inoshandiswa sechinhu chinozadza nzvimbo, ichipinda mukati mepakati pakati pe collagen fibers. Izvi zvose zvinodzivirira nzvimbo dze nucleation dze hydroxyapatite crystals uye inodzivirira kupindira kwe calcium uye phospholipids kubva kune plasma inotakura.

Terminal Kuisa Chisimbiso:

Pakupedzisira, kurapwa neglycine kunoderedza zvakasara, zvinogadzirisa mahara aldehyde mapoka, nokudaro kubvisa chimwe chinhu chinokosha chinokonzera calcification uye cytotoxicity.

2.Outstanding Clinical Results:

Iyi tekinoroji yakashandiswa kune bovine pericardial scaffold inonzi "Periborn." Ongororo yekiriniki yekutevera inofukidza varwere ve352 makore anopfuura 9 yakaratidza rusununguko kubva mukushanda zvakare nekuda kwezvinhu zvine chekuita nechigadzirwa zvakakwirira se95.4%, zvichisimbisa kushanda kweiyi nzira itsva yekurwisa calcification uye kusimba kwayo kwenguva refu.

Kukosha Kwekubudirira Uku:

Iyo haingogadzirise dambudziko renguva refu mumunda webioprosthetic mavharuvhu, kuwedzera hupenyu hwechigadzirwa, asi zvakare inopinza hutsva hutsva mukushandiswa kweglutaraldehyde mune yakakwirira-yekupedzisira biomedical zvinhu.