Munyaya dzemidziyo yemwoyo, glutaraldehyde yagara ichishandiswa kurapa nyama dzemhuka (dzakadai semombe dzinoita se pericardium) pakugadzira mavharuvhu e bioprosthetic. Zvisinei, mapoka e aldehyde akasara kubva mumaitiro echinyakare anogona kutungamira ku calcification mushure mekuiswa, zvichikanganisa kugara kwenguva refu kwezvigadzirwa.
Kugadzirisa dambudziko iri, chidzidzo chazvino chakaburitswa muna Kubvumbi 2025 chakaunza mushonga mutsva wekurwisa calcium (zita rechigadzirwa: Periborn), zvichibudirira zvikuru.
1. Kuvandudzwa Kwetekinoroji Yepakati:
Mhinduro iyi inounza shanduko dzinoverengeka dzakakosha kune maitiro echinyakare ekubatanidza glutaraldehyde:
Kubatanidza Zvinonyungudutsa Zvemuchadenga:
Kubatanidza glutaraldehyde kunoitwa mu organic solvent ine 75% ethanol + 5% octanol. Nzira iyi inobatsira kubvisa zvinobudirira phospholipids dzematishu panguva yekubatanidza cross-linking—phospholipids dziri idzo nzvimbo huru dze nucleation dze calcification.
Mumiriri weKuzadza Nzvimbo:
Mushure mekubatanidza, polyethylene glycol (PEG) inoshandiswa senzira yekuzadza nzvimbo, ichipinza mipata iri pakati pe collagen fibers. Izvi zvinodzivirira nzvimbo dze nucleation dze hydroxyapatite crystals uye zvinodzivirira kupinda kwe calcium ne phospholipids kubva mu plasma.
Kuvhara Chivharo:
Pakupedzisira, kurapwa neglycine kunobvisa mapoka ealdehyde akasara, anokonzera reactive, nokudaro zvichibvisa chimwe chinhu chikuru chinokonzera calcification uye cytotoxicity.
2. Mhedzisiro yekiriniki yakanakisa:
Tekinoroji iyi yakashandiswa pachigadziko chemombe chinonzi "Periborn." Chidzidzo chekutevera chekiriniki chakafukidza varwere 352 mumakore mapfumbamwe chakaratidza kusununguka kubva pakuvhiyiwazve nekuda kwezvinetso zvine chekuita nechigadzirwa kusvika pa95.4%, zvichisimbisa kushanda kwechirongwa ichi chitsva chekudzivirira calcium uye kugara kwenguva refu kwacho kwakanaka.
Kukosha kweKubudirira Uku:
Hazvingogadziri dambudziko renguva refu riripo munyaya dzemavharuvhu ekugadzira zvinhu zvekugadzira, zvichiwedzera hupenyu hwechigadzirwa, asiwo zvinoisa simba idzva mukushandiswa kweglutaraldehyde muzvinhu zvepamusoro-soro zvekurapa.
Nguva yekutumira: Gumiguru-28-2025