Imwe nzira yekuongorora inoverengeka, inoratidzirwa nehupamhi hwepamusoro uye kunzwisiswa kwakasimba, yakagadziridzwa zvakabudirira pakusarudza kwe4,4′-methylene-bis-(2-chloroaniline), inowanzozivikanwa se "MOCA," muweti yemunhu. Izvo zvakakosha kuti uzive kuti MOCA ndeye yakanyatso kunyorwa carcinogen, ine yakasimbiswa toxicological humbowo hunosimbisa carcinogenicity yayo murabhoritari mhuka dzakadai makonzo, mbeva, uye imbwa.
Vasati vashandisa iyi nzira ichangobva kugadzirwa mumamiriro ekushanda epasirese, boka rekutsvagisa rakatanga kuita ongororo yenguva pfupi yekushandisa makonzo. Chinangwa chikuru cheiyi preclinical study yaive yekuona nekujekesa zvimwe zvakakosha zvine chekuita nekubuda weti kweMOCA mumuenzaniso wemhuka-kusanganisira zvinhu zvakaita seyekubuda, nzira dzemasabolism, uye nguva yefafitera yemazinga anooneka-kuisa hwaro hwakasimba hwesainzi hwekushandiswa kunotevera kwenzira mumasampuli evanhu.
Zvichitevera kupedzwa uye kusimbiswa kwechidzidzo chepamberi, iyi nzira yekuongorora weti yakashandiswa zviri pamutemo kuongorora huwandu hwekuratidzwa kwebasa kuMOCA pakati pevashandi mumabhizinesi emaindasitiri eFrance. Kukura kweongororo kwakabata mhando mbiri huru dzezviitiko zvebasa zvine hukama zvakanyanya neMOCA: imwe yaive nzira yekugadzira maindasitiri yeMOCA pachayo, uye imwe yacho yaive kushandiswa kweMOCA semushonga wekurapa mukugadzira polyurethane elastomers, chiitiko chakajairwa chekushandisa mumaindasitiri emakemikari nezvemidziyo.
Kuburikidza nekuyedzwa kukuru kwemasamples eweti akaunganidzwa kubva kuvashandi mumamiriro ezvinhu aya, boka rekutsvagisa rakaona kuti kubuda kweweti kweMOCA kwakaratidza mutsauko wakasiyana. Kunyanya, iyo excretion concentrations yakabva kune isingaonekwi mazinga-anotsanangurwa seasingasviki 0.5 microgram per litre-kusvika pakukwirira kwe1,600 micrograms per litre. Uyezve, apo N-acetyl metabolites yeMOCA yaivepo mumasampuli eweti, kuwanda kwavo kwaive kwakadzikama uye kwakadzikira zvakanyanya pane kuwanda kwechikamu chevabereki (MOCA) mumasamples akafanana, zvichiratidza kuti MOCA pachayo ndiyo yekutanga fomu yakaburitswa muweti uye chiratidzo chakavimbika chekufumura.
Pakazere, mibairo yakawanikwa kubva muhukuru-hukuru hwekufumurwa ongororo yebasa yakaratidza zvakaringana uye nemazvo kuratidzwa kwese kweMOCA mazinga evashandi vakaongororwa, sezvo iwo akaonekwa mazinga ekubuda ainyatsoenderana nechimiro chebasa ravo, nguva yekuratidzwa, uye mamiriro enzvimbo yekushanda. Uyezve, zvakakosha zvakacherechedzwa kubva muchidzidzo ndezvekuti mushure mekunge kuongororwa kwapera uye matanho ekudzivirira akaiswa munzvimbo dzebasa - sekuvandudza masystem ekufemesa, kusimudzira mashandisirwo emidziyo yekudzivirira (PPE), kana optimize maitiro ekuita - iyo urinary excretion mazinga eMOCA muvashandi vakabatwa kazhinji yakaratidza kuderera kuri pachena uye kwakakosha kwekudzivirira kwekuita kwekuita kuderera kwekuita izvi. kusangana neMOCA.
Nguva yekutumira: Oct-11-2025